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KMID : 0357119940160040331
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Korean Journal of Immunology
1994 Volume.16 No. 4 p.331 ~ p.338
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IL-2 Production and Mitogen-induced Proliferation Responses in Splenocytes of Tumor Bearing Mice
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Abstract
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The development of an immune resonse to a growing tumor requires the participation of a variety of host immune components, which include both cellular and soluble mediators. Therefore, the investigation of the immunological status of
tumor-bearing
host
may provide important insights into the role of endogenouse immune responses in the control of tumor growth. The purpose of the present stuty was to examine the mitogenic responses and interleukin(IL)-2 production in splenocytes or thymocytes as
tumor
progression take place. Tumor was induced by intradermal injection of 5×10E5 B16 melanoma cells in shaved abdominal belly region on day 0, and the tumor growth was measured by changing against time. The thymus and spleen cells from various time
of
tumor-bearing mice(TBM) were tested for their capacities to produce IL-2. The peak response of IL-2 production was observed from spleen cells of 16-day-TBM, and this response was gradually reduced thereafter up to 42 days. Thus, these results
indicate
that decreased IL-2 production observed at later tumor-bearing stages may be due to functional disturbance of the total capacity of spleen cells to produce this lymphokine. The proliferation response of spleen cells to PHA or Con A was also
gradually
depressed and response to SAC or LJPS was enhanced at 16-and 25-dya-TBM but depressed at 42-dya TBM. Taken together, the present study suggests that cell proliferlation response and IL-2 production of the thymus and spleen cells were depressed in
the
tumor bearing mice.
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